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The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial.

ABSTRACT: Paracetamol's (APAP) mechanism of action suggests the implication of supraspinal structures but no neuroimaging study has been performed in humans.This randomized, double-blind, crossover, placebo-controlled trial in 17 healthy volunteers (NCT01562704) aimed to evaluate how APAP modulates pain-evoked functional magnetic resonance imaging signals. We used behavioral measures and functional magnetic resonance imaging to investigate the response to experimental thermal stimuli with APAP or placebo administration. Region-of-interest analysis revealed that activity in response to noxious stimulation diminished with APAP compared to placebo in prefrontal cortices, insula, thalami, anterior cingulate cortex, and periaqueductal gray matter.These findings suggest an inhibitory effect of APAP on spinothalamic tracts leading to a decreased activation of higher structures, and a top-down influence on descending inhibition. Further binding and connectivity studies are needed to evaluate how APAP modulates pain, especially in the context of repeated administration to patients with pain.

SUBMITTER: Pickering G

PROVIDER: S-EPMC4517518 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial.

Pickering Gisèle G Kastler Adrian A Macian Nicolas N Pereira Bruno B Valabrègue Romain R Lehericy Stéphane S Boyer Louis L Dubray Claude C Jean Betty B

Drug design, development and therapy 20150723

<h4>Background</h4>Paracetamol's (APAP) mechanism of action suggests the implication of supraspinal structures but no neuroimaging study has been performed in humans.<h4>Methods and results</h4>This randomized, double-blind, crossover, placebo-controlled trial in 17 healthy volunteers (NCT01562704) aimed to evaluate how APAP modulates pain-evoked functional magnetic resonance imaging signals. We used behavioral measures and functional magnetic resonance imaging to investigate the response to exp ...[more]

PMID: 26229445

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The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial.

Publications

The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial.

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