Ontology highlight
ABSTRACT:
SUBMITTER: Johnson RE
PROVIDER: S-EPMC4517859 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20150702 2
Genetic studies with S. cerevisiae Polδ (pol3-L612M) and Polε (pol2-M644G) mutant alleles, each of which display a higher rate for the generation of a specific mismatch, have led to the conclusion that Polε is the primary leading strand replicase and that Polδ is restricted to replicating the lagging strand template. Contrary to this widely accepted view, here we show that Polδ plays a major role in the replication of both DNA strands, and that the paucity of pol3-L612M-generated errors on the l ...[more]