Ontology highlight
ABSTRACT:
SUBMITTER: Wang SH
PROVIDER: S-EPMC4517890 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150728 7
Chemo- and radiotherapy cause multiple forms of DNA damage and lead to the death of cancer cells. Inhibitors of the DNA damage response are candidate drugs for use in combination therapies to increase the efficacy of such treatments. In this study, we show that curcumin, a plant polyphenol, sensitizes budding yeast to DNA damage by counteracting the DNA damage response. Following DNA damage, the Mec1-dependent DNA damage checkpoint is inactivated and Rad52 recombinase is degraded by curcumin, wh ...[more]