Ontology highlight
ABSTRACT:
SUBMITTER: Lee MS
PROVIDER: S-EPMC4518267 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nature communications 20150717
The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabilization is induced by EGFR- or oncogenic PI3K mutation-mediated AKT activation in cervical cancer. EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase. The ...[more]