Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4518313 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Li June J van der Wal Dianne E DE Zhu Guangheng G Xu Miao M Yougbare Issaka I Ma Li L Vadasz Brian B Carrim Naadiya N Grozovsky Renata R Ruan Min M Zhu Lingyan L Zeng Qingshu Q Tao Lili L Zhai Zhi-min ZM Peng Jun J Hou Ming M Leytin Valery V Freedman John J Hoffmeister Karin M KM Ni Heyu H
Nature communications 20150717
Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests that antibody-mediated platelet destruction occurs in the spleen, via macrophages through Fc-FcγR interactions. However, we and others have demonstrated that anti-GPIbα (but not GPIIbIIIa)-mediated ITP is often refractory to therapies targeting FcγR pathways. Here, we generate mouse anti-mouse monoclonal antibodies (mAbs) that ...[more]