Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia.
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ABSTRACT:
SUBMITTER: Tao L
PROVIDER: S-EPMC5304552 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia.
Tao Lili L Zeng Qingshu Q Li June J Xu Miao M Wang Jiajia J Pan Ying Y Wang Huiping H Tao Qianshan Q Chen Yang Y Peng Jun J Hou Ming M Jansen Arend Jan Gerard AJ Ni Heyu H Zhai Zhimin Z
Journal of hematology & oncology 20170208 1
Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. Despite considerable investigation, the pathogenesis of ITP remains incompletely understood, and for many patients, effective therapy is still unavailable. Using murine models and in vitro studies of human blood samples, we recently identified a novel Fc-independent platelet clearance pathway, whereby antibody-mediated desialylated platelets can be cleared in the liver via asialoglycoprotein receptors, leading to decreased r ...[more]
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