Ontology highlight
ABSTRACT:
SUBMITTER: Kolev M
PROVIDER: S-EPMC4518498 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Kolev Martin M Dimeloe Sarah S Le Friec Gaelle G Navarini Alexander A Arbore Giuseppina G Povoleri Giovanni A GA Fischer Marco M Belle Réka R Loeliger Jordan J Develioglu Leyla L Bantug Glenn R GR Watson Julie J Couzi Lionel L Afzali Behdad B Lavender Paul P Hess Christoph C Kemper Claudia C
Immunity 20150601 6
Expansion and acquisition of Th1 cell effector function requires metabolic reprogramming; however, the signals instructing these adaptations remain poorly defined. Here we found that in activated human T cells, autocrine stimulation of the complement receptor CD46, and specifically its intracellular domain CYT-1, was required for induction of the amino acid (AA) transporter LAT1 and enhanced expression of the glucose transporter GLUT1. Furthermore, CD46 activation simultaneously drove expression ...[more]