Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC6051420 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cell reports 20180501 6
T cells are strongly regulated by oxidizing environments and amino acid restriction. How T cells reprogram metabolism to adapt to these extracellular stress situations is not well understood. Here, we show that oxidizing environments and amino acid starvation induce ATF4 in CD4<sup>+</sup> T cells. We also demonstrate that Atf4-deficient CD4<sup>+</sup> T cells have defects in redox homeostasis, proliferation, differentiation, and cytokine production. We further reveal that ATF4 regulates a coor ...[more]