Ontology highlight
ABSTRACT:
SUBMITTER: Patel HJ
PROVIDER: S-EPMC4518544 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Patel Hardik J HJ Patel Pallav D PD Ochiana Stefan O SO Yan Pengrong P Sun Weilin W Patel Maulik R MR Shah Smit K SK Tramentozzi Elisa E Brooks James J Bolaender Alexander A Shrestha Liza L Stephani Ralph R Finotti Paola P Leifer Cynthia C Li Zihai Z Gewirth Daniel T DT Taldone Tony T Chiosis Gabriela G
Journal of medicinal chemistry 20150422 9
Grp94 is involved in the regulation of a restricted number of proteins and represents a potential target in a host of diseases, including cancer, septic shock, autoimmune diseases, chronic inflammatory conditions, diabetes, coronary thrombosis, and stroke. We have recently identified a novel allosteric pocket located in the Grp94 N-terminal binding site that can be used to design ligands with a 2-log selectivity over the other Hsp90 paralogs. Here we perform extensive SAR investigations in this ...[more]