Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh S
PROVIDER: S-EPMC4861406 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Ghosh Suman S Shinogle Heather E HE Galeva Nadezhda A NA Dobrowsky Rick T RT Blagg Brian S J BS
The Journal of biological chemistry 20160212 16
Heat shock protein 90 (HSP90) is a molecular chaperone that is up-regulated in cancer and is required for the folding of numerous signaling proteins. Consequently, HSP90 represents an ideal target for the development of new anti-cancer agents. The human HSP90 isoform, glucose-regulated protein 94 (GRP94), resides in the endoplasmic reticulum and regulates secretory pathways, integrins, and Toll-like receptors, which contribute to regulating immunity and metastasis. However, the cellular function ...[more]