Ontology highlight
ABSTRACT:
SUBMITTER: D'Hulst C
PROVIDER: S-EPMC4519313 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
D'Hulst Charlotte C Heulens Inge I Van der Aa Nathalie N Goffin Karolien K Koole Michel M Porke Kathleen K Van De Velde Marc M Rooms Liesbeth L Van Paesschen Wim W Van Esch Hilde H Van Laere Koen K Kooy R Frank RF
PloS one 20150729 7
Over the last several years, evidence has accumulated that the GABAA receptor is compromised in animal models for fragile X syndrome (FXS), a common hereditary form of intellectual disability. In mouse and fly models, agonists of the GABAA receptor were able to rescue specific consequences of the fragile X mutation. Here, we imaged and quantified GABAA receptors in vivo in brain of fragile X patients using Positron Emission Topography (PET) and [11C]flumazenil, a known high-affinity and specific ...[more]