Regulation and function of the human HSP90AA1 gene.
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ABSTRACT:
SUBMITTER: Zuehlke AD
PROVIDER: S-EPMC4519370 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Regulation and function of the human HSP90AA1 gene.
Zuehlke Abbey D AD Beebe Kristin K Neckers Len L Prince Thomas T
Gene 20150610 1
Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins. These differences are likely due to variations in nucleotide sequence within non-coding regions, which allows for specific regulation through interaction with particular transcripti ...[more]
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