Ontology highlight
ABSTRACT:
SUBMITTER: Brown AC
PROVIDER: S-EPMC4519427 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Brown Aaron C AC Muthukrishnan Sree Deepthi SD Oxburgh Leif L
Developmental cell 20150716 2
FGF, BMP, and WNT balance embryonic nephron progenitor cell (NPC) renewal and differentiation. By modulating these pathways, we have created an in vitro niche in which NPCs from embryonic kidneys or derived from human embryonic stem cells can be propagated. NPC cultures expanded up to one billion-fold in this environment can be induced to form tubules expressing nephron differentiation markers. Single-cell culture reveals phenotypic variability within the early CITED1-expressing NPC compartment, ...[more]