Structural Diversity of Copper(II) Complexes with 9-Deazahypoxanthine and Their in Vitro SOD-Like Activity.
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ABSTRACT:
SUBMITTER: Galikova J
PROVIDER: S-EPMC4519932 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:The solvent-induced topological and structural diversities of two Co(II) complexes, namely, [Co(L)2(SCN)2] (Co1) and [Co2(L)2(SCN)(OAc)3] (Co2) (L = 8-methoxyquinoline), were comparatively analyzed. Certain proportions of L, Co(OAc)2·4H2O, and NaSCN were mixed and dissolved in CH3OH at 60 °C to obtain complex Co1. Complex Co2, an asymmetric dinuclear compound, was obtained by simply replacing CH3OH with CH3CN as the solvent. The Co(II) ion in complex Co1 was coordinated by the N4O2 mode provided by two L ligands and two SCN- anions. The two Co(II) ions in Co2 were in the N2O4 and NO5 coordination environment and were linked by two ?2-OAc- bridges and one rare ?3-OAc- bridge. Weak interaction analysis revealed that complexes Co1 and Co2 exhibited 6-connected shp and 14-connected fcu nets, respectively. Magnetic studies showed that Co1 demonstrated single-ion magnet behavior under 2000 Oe. These behaviors are indicative of clearly field-induced single-ion magnetic behavior with U eff = 34.7(2) K and ?0 = 2.7(2) × 10-7 s under 2000 Oe dc field, respectively. By contrast, Co2 lacked frequency dependence under zero-field conditions. Electrospray ionization mass spectrometry indicated that two complexes were stable in N,N-dimethylformamide.
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Project description:Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CH3OH)]·CH3OH (1), [Ni(naph-L-phe)(phen)(CH3OH)] (2), and [Ni(o-van-L-phe)(phen)(CH3OH)]·5CH3OH (3) (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, o-van-L-phe = a Schiff base derived from o-vanillin and L-phenylalanine, and phen = 1,10-phenanthroline), have been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. The interactions of these complexes with CT-DNA were studied by UV-Vis absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy, and viscosity measurements. The binding constant (Kb) values of 1.82 × 104 M-1 for 1, 1.96 × 104 M-1 for 2, and 2.02 × 104 M-1 for 3 suggest that each of these complexes could bind with DNA in a moderate intercalative mode. Complex 3 exhibited a stronger interaction with CT-DNA than complexes 1 and 2. In addition, the superoxide scavenging activity of these complexes was investigated by the nitrotetrazolium blue chloride (NBT) light reduction method, and the results showed that they exhibited a significant superoxide scavenging activity with the IC50 values of 4.4 × 10-5 M for complex 1, 5.6 × 10-5 M for complex 2, and 3.1 × 10-5 M for complex 3, respectively.
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