Heat shock protein vaccines against glioblastoma: from bench to bedside.
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ABSTRACT:
SUBMITTER: Ampie L
PROVIDER: S-EPMC4520407 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Heat shock protein vaccines against glioblastoma: from bench to bedside.
Ampie Leonel L Choy Winward W Lamano Jonathan B JB Fakurnejad Shayan S Bloch Orin O Parsa Andrew T AT
Journal of neuro-oncology 20150621 3
Current adjuvant treatment regimens available for the treatment of glioblastoma are widely ineffective and offer a dismal prognosis. Advancements in conventional treatment strategies have only yielded modest improvements in overall survival. Immunotherapy remains a promising adjuvant in the treatment of GBM through eliciting tumor specific immune responses capable of producing sustained antitumor response while minimizing systemic toxicity. Heat shock proteins (HSP) function as intracellular cha ...[more]
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