Ontology highlight
ABSTRACT:
SUBMITTER: Pepin KM
PROVIDER: S-EPMC4520436 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Pepin K M KM Riley S S Grenfell B T BT
Epidemiology and infection 20120330 2
Antivirals are an important defence against novel strains of influenza. However, the impact of widespread drug usage on strain circulation across multiple epidemic waves - via their impact on host immunity - is unknown despite antivirals having the likelihood of extensive use during a pandemic. To explore how drug usage by individuals affects population strain dynamics, we embedded a two-strain model of within-host dynamics within an epidemic model. We found that when 40% of hosts took drugs ear ...[more]