Ontology highlight
ABSTRACT:
SUBMITTER: Mahata B
PROVIDER: S-EPMC4520498 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150730 7
Previously we demonstrated that human glioblastoma cell lines induce apoptosis in peripheral blood T cells through partial involvement of secreted gangliosides. Here we show that GBM-derived gangliosides induce apoptosis through involvement of the TNF receptor and activation of the caspase cascade. Culturing T lymphocytes with GBM cell line derived gangliosides (10-20 μg/ml) demonstrated increased ROS production as early as 18 hrs as indicated by increased uptake of the dye H2DCFDA while western ...[more]