Quantifying the uncertainty in heritability.
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ABSTRACT:
SUBMITTER: Furlotte NA
PROVIDER: S-EPMC4521294 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Quantifying the uncertainty in heritability.
Furlotte Nicholas A NA Heckerman David D Lippert Christoph C
Journal of human genetics 20140327 5
The use of mixed models to determine narrow-sense heritability and related quantities such as SNP heritability has received much recent attention. Less attention has been paid to the inherent variability in these estimates. One approach for quantifying variability in estimates of heritability is a frequentist approach, in which heritability is estimated using maximum likelihood and its variance is quantified through an asymptotic normal approximation. An alternative approach is to quantify the u ...[more]
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