Ontology highlight
ABSTRACT:
SUBMITTER: Zong H
PROVIDER: S-EPMC4522184 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Zong Hong H Shah Dhavan D Selwa Katherine K Tsuchida Ryan E RE Rattan Rahul R Mohan Jay J Stein Adam B AB Otis James B JB Goonewardena Sascha N SN
ChemistryOpen 20150413 3
Histone deacetylase inhibitors (HDACi) are promising therapeutics for cancer. HDACi alter the epigenetic state of tumors and provide a unique approach to treat cancer. Although studies with HDACi have shown promise in some cancers, variable efficacy and off-target effects have limited their use. To overcome some of the challenges of traditional HDACi, we sought to use a tumor-specific dendrimer scaffold to deliver HDACi directly to cancer cells. Here we report the design and evaluation of tumor- ...[more]