Ontology highlight
ABSTRACT:
SUBMITTER: Dong Z
PROVIDER: S-EPMC4522399 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Dong Zhongqi Z Li Qing Q Guo Dong D Shu Yan Y Polli James E JE
Journal of pharmaceutical sciences 20150202 9
Ribavirin is used to treat hepatitis C but causes serious hemolytic anemia. The objective of the study was to develop a ribavirin prodrug to achieve liver-specific drug delivery and to reduce its off-target effect in red blood cells (RBCs). The approach aimed to target the human sodium taurocholate cotransporting polypeptide (NTCP), which is a bile acid transporter predominately expressed in the liver. Six prodrugs with ribavirin conjugation at C-3 or C-24 of the bile acids were synthesized. In ...[more]