Ontology highlight
ABSTRACT:
SUBMITTER: Kahnt M
PROVIDER: S-EPMC6630699 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190617 12
In this study, we report the synthesis of several amine-spacered conjugates of ursolic acid (UA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). Thus, a total of 11 UA-DOTA conjugates were prepared holding various oligo-methylene diamine spacers as well as different substituents at the acetate units of DOTA including <i>tert</i>-butyl, benzyl, and allyl esters. Furthermore, three synthetic approaches were compared for the ethylenediamine-spacered conjugate <b>29</b> regardin ...[more]