Ontology highlight
ABSTRACT:
SUBMITTER: Sun GJ
PROVIDER: S-EPMC4522763 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Sun Gerald J GJ Zhou Yi Y Stadel Ryan P RP Moss Jonathan J Yong Jing Hui A JH Ito Shiori S Kawasaki Nicholas K NK Phan Alexander T AT Oh Justin H JH Modak Nikhil N Reed Randall R RR Toni Nicolas N Song Hongjun H Ming Guo-li GL
Proceedings of the National Academy of Sciences of the United States of America 20150713 30
In a classic model of mammalian brain formation, precursors of principal glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precursors migrate tangentially. These migration modes have significant implications for brain function. Here we used clonal lineage tracing of active radial glia-like neural stem cells in the adult mouse dentate gyrus and made the surprising discovery that proliferating neuronal precursors of glutamatergic granule neurons exhibit ...[more]