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Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.


ABSTRACT: In a classic model of mammalian brain formation, precursors of principal glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precursors migrate tangentially. These migration modes have significant implications for brain function. Here we used clonal lineage tracing of active radial glia-like neural stem cells in the adult mouse dentate gyrus and made the surprising discovery that proliferating neuronal precursors of glutamatergic granule neurons exhibit significant tangential migration along blood vessels, followed by limited radial migration. Genetic birthdating and morphological and molecular analyses pinpointed the neuroblast stage as the main developmental window when tangential migration occurs. We also developed a partial "whole-mount" dentate gyrus preparation and observed a dense plexus of capillaries, with which only neuroblasts, among the entire population of progenitors, are directly associated. Together, these results provide insight into neuronal migration in the adult mammalian nervous system.

SUBMITTER: Sun GJ 

PROVIDER: S-EPMC4522763 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.

Sun Gerald J GJ   Zhou Yi Y   Stadel Ryan P RP   Moss Jonathan J   Yong Jing Hui A JH   Ito Shiori S   Kawasaki Nicholas K NK   Phan Alexander T AT   Oh Justin H JH   Modak Nikhil N   Reed Randall R RR   Toni Nicolas N   Song Hongjun H   Ming Guo-li GL  

Proceedings of the National Academy of Sciences of the United States of America 20150713 30


In a classic model of mammalian brain formation, precursors of principal glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precursors migrate tangentially. These migration modes have significant implications for brain function. Here we used clonal lineage tracing of active radial glia-like neural stem cells in the adult mouse dentate gyrus and made the surprising discovery that proliferating neuronal precursors of glutamatergic granule neurons exhibit  ...[more]

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