Ontology highlight
ABSTRACT:
SUBMITTER: Uda Y
PROVIDER: S-EPMC4834041 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Uda Youichi Y Xu Shuai S Matsumura Takafumi T Takei Yoshinori Y
Stem cell reports 20160310 4
Neural stem cells (NSCs) produce all neuronal subtypes involved in the nervous system. The mechanism regulating their subtype selection is not fully understood. We found that the expression of the nucleotide receptor P2Y4 was transiently augmented in the course of neuronal differentiation of mouse embryonic stem cells (ESCs), which was after loss of pluripotency but prior to terminal differentiation of neurons. The activation of P2Y4 in the differentiating ESCs resulted in an increased proportio ...[more]