Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3?.
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ABSTRACT:
SUBMITTER: Fala AM
PROVIDER: S-EPMC4522956 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α.
Fala Angela M AM Oliveira Juliana F JF Adamoski Douglas D Aricetti Juliana A JA Dias Marilia M MM Dias Marcio V B MVB Sforça Maurício L ML Lopes-de-Oliveira Paulo S PS Rocco Silvana A SA Caldana Camila C Dias Sandra M G SMG Ambrosio Andre L B ALB
Scientific reports 20150803
Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. Here we report novel evidence showing that unsaturated fatty acids are naturally occurring, non-covalent structural ligands of HIF-3α, thus providing the initial framework for explor ...[more]
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