Ontology highlight
ABSTRACT:
SUBMITTER: Rajasingh S
PROVIDER: S-EPMC4523188 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Rajasingh Sheeja S Thangavel Jayakumar J Czirok Andras A Samanta Saheli S Roby Katherine F KF Dawn Buddhadeb B Rajasingh Johnson J
PloS one 20150803 8
Human induced pluripotent stem cells (iPSCs) derived cardiomyocytes (iCMCs) would provide an unlimited cell source for regenerative medicine and drug discoveries. The objective of our study is to generate functional cardiomyocytes from human iPSCs and to develop a novel method of measuring contractility of CMCs. In a series of experiments, adult human skin fibroblasts (HSF) and human umbilical vein endothelial cells (HUVECs) were treated with a combination of pluripotent gene DNA and mRNA under ...[more]