Ontology highlight
ABSTRACT:
SUBMITTER: Santra S
PROVIDER: S-EPMC4523205 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Santra Sampa S Tomaras Georgia D GD Warrier Ranjit R Nicely Nathan I NI Liao Hua-Xin HX Pollara Justin J Liu Pinghuang P Alam S Munir SM Zhang Ruijun R Cocklin Sarah L SL Shen Xiaoying X Duffy Ryan R Xia Shi-Mao SM Schutte Robert J RJ Pemble Iv Charles W CW Dennison S Moses SM Li Hui H Chao Andrew A Vidnovic Kora K Evans Abbey A Klein Katja K Kumar Amit A Robinson James J Landucci Gary G Forthal Donald N DN Montefiori David C DC Kaewkungwal Jaranit J Nitayaphan Sorachai S Pitisuttithum Punnee P Rerks-Ngarm Supachai S Robb Merlin L ML Michael Nelson L NL Kim Jerome H JH Soderberg Kelly A KA Giorgi Elena E EE Blair Lily L Korber Bette T BT Moog Christiane C Shattock Robin J RJ Letvin Norman L NL Schmitz Joern E JE Moody M A MA Gao Feng F Ferrari Guido G Shaw George M GM Haynes Barton F BF
PLoS pathogens 20150803 8
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies that are most likely protective, they are not induced with current vaccine candidates. In contrast, antibodies that do not neutralize primary HIV-1 strains in the TZM-bl infection assay are readily induced by current vaccine candidates and have also been implicated as secondary ...[more]