Ontology highlight
ABSTRACT:
SUBMITTER: Hessell AJ
PROVIDER: S-EPMC4983100 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Hessell Ann J AJ Jaworski J Pablo JP Epson Erin E Matsuda Kenta K Pandey Shilpi S Kahl Christoph C Reed Jason J Sutton William F WF Hammond Katherine B KB Cheever Tracy A TA Barnette Philip T PT Legasse Alfred W AW Planer Shannon S Stanton Jeffrey J JJ Pegu Amarendra A Chen Xuejun X Wang Keyun K Siess Don D Burke David D Park Byung S BS Axthelm Michael K MK Lewis Anne A Hirsch Vanessa M VM Graham Barney S BS Mascola John R JR Sacha Jonah B JB Haigwood Nancy L NL
Nature medicine 20160321 4
Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1-specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified sy ...[more]