Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC4523434 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Kim Hana H Bhattacharya Asmita A Qi Ling L
Seminars in cancer biology 20150318
Quality control systems in the endoplasmic reticulum (ER) mediated by unfolded protein response (UPR) and endoplasmic reticulum associated degradation (ERAD) ensure cellular function and organismal survival. Recent studies have suggested that ER quality-control systems in cancer cells may serve as a double-edged sword that aids progression as well as prevention of tumor growth in a context-dependent manner. Here we review recent advances in our understanding of the complex relationship between E ...[more]