DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.
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ABSTRACT:
SUBMITTER: Northcutt AL
PROVIDER: S-EPMC4523496 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.
Northcutt A L AL Hutchinson M R MR Wang X X Baratta M V MV Hiranita T T Cochran T A TA Pomrenze M B MB Galer E L EL Kopajtic T A TA Li C M CM Amat J J Larson G G Cooper D C DC Huang Y Y O'Neill C E CE Yin H H Zahniser N R NR Katz J L JL Rice K C KC Maier S F SF Bachtell R K RK Watkins L R LR
Molecular psychiatry 20150203 12
The initial reinforcing properties of drugs of abuse, such as cocaine, are largely attributed to their ability to activate the mesolimbic dopamine system. Resulting increases in extracellular dopamine in the nucleus accumbens (NAc) are traditionally thought to result from cocaine's ability to block dopamine transporters (DATs). Here we demonstrate that cocaine also interacts with the immunosurveillance receptor complex, Toll-like receptor 4 (TLR4), on microglial cells to initiate central innate ...[more]
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