Ontology highlight
ABSTRACT:
SUBMITTER: Sutani T
PROVIDER: S-EPMC4525155 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Sutani Takashi T Sakata Toyonori T Nakato Ryuichiro R Masuda Koji K Ishibashi Mai M Yamashita Daisuke D Suzuki Yutaka Y Hirano Tatsuya T Bando Masashige M Shirahige Katsuhiko K
Nature communications 20150723
Chromosome condensation is a hallmark of mitosis in eukaryotes and is a prerequisite for faithful segregation of genetic material to daughter cells. Here we show that condensin, which is essential for assembling condensed chromosomes, helps to preclude the detrimental effects of gene transcription on mitotic condensation. ChIP-seq profiling reveals that the fission yeast condensin preferentially binds to active protein-coding genes in a transcription-dependent manner during mitosis. Pharmacologi ...[more]