Ontology highlight
ABSTRACT:
SUBMITTER: Soulard V
PROVIDER: S-EPMC4525212 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Soulard Valérie V Bosson-Vanga Henriette H Lorthiois Audrey A Roucher Clémentine C Franetich Jean-François JF Zanghi Gigliola G Bordessoulles Mallaury M Tefit Maurel M Thellier Marc M Morosan Serban S Le Naour Gilles G Capron Frédérique F Suemizu Hiroshi H Snounou Georges G Moreno-Sabater Alicia A Mazier Dominique D
Nature communications 20150724
Experimental studies of Plasmodium parasites that infect humans are restricted by their host specificity. Humanized mice offer a means to overcome this and further provide the opportunity to observe the parasites in vivo. Here we improve on previous protocols to achieve efficient double engraftment of TK-NOG mice by human primary hepatocytes and red blood cells. Thus, we obtain the complete hepatic development of P. falciparum, the transition to the erythrocytic stages, their subsequent multipli ...[more]