Ontology highlight
ABSTRACT:
SUBMITTER: Matsui M
PROVIDER: S-EPMC4525381 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Matsui Masayuki M Li Liande L Janowski Bethany A BA Corey David R DR
Scientific reports 20150805
Until recently, Argonaute 2 (AGO2) and other RNA factors were believed to be restricted to the cytoplasm of mammalian somatic cells. It is now becoming appreciated that RNAi factors can also be found in cell nuclei, but much remains to be learned about their transport, molecular recognition, and function. We find that siRNA-mediated reduction of AGO1 or AGO2 increases the proportion of AGO1 or AGO2 in cell nuclei. Inhibition of AGO1 expression led to increased AGO2 levels, while knockdown of AGO ...[more]