Ontology highlight
ABSTRACT:
SUBMITTER: Rafnar T
PROVIDER: S-EPMC4525478 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Rafnar Thorunn T Sulem Patrick P Stacey Simon N SN Geller Frank F Gudmundsson Julius J Sigurdsson Asgeir A Jakobsdottir Margret M Helgadottir Hafdis H Thorlacius Steinunn S Aben Katja K H KK Blöndal Thorarinn T Thorgeirsson Thorgeir E TE Thorleifsson Gudmar G Kristjansson Kristleifur K Thorisdottir Kristin K Ragnarsson Rafn R Sigurgeirsson Bardur B Skuladottir Halla H Gudbjartsson Tomas T Isaksson Helgi J HJ Einarsson Gudmundur V GV Benediktsdottir Kristrun R KR Agnarsson Bjarni A BA Olafsson Karl K Salvarsdottir Anna A Bjarnason Hjordis H Asgeirsdottir Margret M Kristinsson Kari T KT Matthiasdottir Sigurborg S Sveinsdottir Steinunn G SG Polidoro Silvia S Höiom Veronica V Botella-Estrada Rafael R Hemminki Kari K Rudnai Peter P Bishop D Timothy DT Campagna Marcello M Kellen Eliane E Zeegers Maurice P MP de Verdier Petra P Ferrer Ana A Isla Dolores D Vidal Maria Jesus MJ Andres Raquel R Saez Berta B Juberias Pablo P Banzo Javier J Navarrete Sebastian S Tres Alejandro A Kan Donghui D Lindblom Annika A Gurzau Eugene E Koppova Kvetoslava K de Vegt Femmie F Schalken Jack A JA van der Heijden Henricus F M HF Smit Hans J HJ Termeer René A RA Oosterwijk Egbert E van Hooij Onno O Nagore Eduardo E Porru Stefano S Steineck Gunnar G Hansson Johan J Buntinx Frank F Catalona William J WJ Matullo Giuseppe G Vineis Paolo P Kiltie Anne E AE Mayordomo José I JI Kumar Rajiv R Kiemeney Lambertus A LA Frigge Michael L ML Jonsson Thorvaldur T Saemundsson Hafsteinn H Barkardottir Rosa B RB Jonsson Eirikur E Jonsson Steinn S Olafsson Jon H JH Gulcher Jeffrey R JR Masson Gisli G Gudbjartsson Daniel F DF Kong Augustine A Thorsteinsdottir Unnur U Stefansson Kari K
Nature genetics 20090118 2
The common sequence variants that have recently been associated with cancer risk are particular to a single cancer type or at most two. Following up on our genome-wide scan of basal cell carcinoma, we found that rs401681[C] on chromosome 5p15.33 satisfied our threshold for genome-wide significance (OR = 1.25, P = 3.7 x 10(-12)). We tested rs401681 for association with 16 additional cancer types in over 30,000 cancer cases and 45,000 controls and found association with lung cancer (OR = 1.15, P = ...[more]