Ontology highlight
ABSTRACT:
SUBMITTER: Depetris RS
PROVIDER: S-EPMC4526137 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Depetris Rafael S RS Hu Junjie J Gimpelevich Ilana I Holt Lowenna J LJ Daly Roger J RJ Hubbard Stevan R SR
Molecular cell 20051001 2
Grb14, a member of the Grb7 adaptor protein family, possesses a pleckstrin homology (PH) domain, a C-terminal Src homology-2 (SH2) domain, and an intervening stretch of approximately 45 residues known as the BPS region, which is unique to this adaptor family. Previous studies have demonstrated that Grb14 is a tissue-specific negative regulator of insulin receptor signaling and that inhibition is mediated by the BPS region. We have determined the crystal structure of the Grb14 BPS region in compl ...[more]