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Dynamic aberrant NF-?B spurs tumorigenesis: a new model encompassing the microenvironment.

ABSTRACT: Recently it was discovered that a transient activation of transcription factor NF-?B can give cells properties essential for invasiveness and cancer initiating potential. In contrast, most oncogenes to date were characterized on the basis of mutations or by their constitutive overexpression. Study of NF-?B actually leads to a far more dynamic perspective on cancer: tumors caused by diverse oncogenes apparently evolve into cancer after loss of feedback regulation for NF-?B. This event alters the cellular phenotype and the expression of hormonal mediators, modifying signals between diverse cell types in a tissue. The result is a disruption of stem cell hierarchy in the tissue, and pervasive changes in the microenvironment and immune response to the malignant cells.

SUBMITTER: Vlahopoulos SA

PROVIDER: S-EPMC4526340 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment.

Vlahopoulos Spiros A SA Cen Osman O Hengen Nina N Agan James J Moschovi Maria M Critselis Elena E Adamaki Maria M Bacopoulou Flora F Copland John A JA Boldogh Istvan I Karin Michael M Chrousos George P GP

Cytokine & growth factor reviews 20150620 4

Recently it was discovered that a transient activation of transcription factor NF-κB can give cells properties essential for invasiveness and cancer initiating potential. In contrast, most oncogenes to date were characterized on the basis of mutations or by their constitutive overexpression. Study of NF-κB actually leads to a far more dynamic perspective on cancer: tumors caused by diverse oncogenes apparently evolve into cancer after loss of feedback regulation for NF-κB. This event alters the ...[more]

PMID: 26119834

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