Unknown

Dataset Information

0

Sources of dynamic variability in NF-κB signal transduction: a mechanistic model.


ABSTRACT: The transcription factor NF-κB (p65/p50) plays a central role in the coordination of cellular responses by activating the transcription of numerous target genes. The precise role of the dynamics of NF-κB signalling in regulating gene expression is still an open question. Here, we show that besides external stimulation intracellular parameters can influence the dynamics of NF-κB. By applying mathematical modelling and bifurcation analyses, we show that NF-κB is capable of exhibiting different types of dynamics in response to the same stimulus. We identified the total NF-κB concentration and the IκBα transcription rate constant as two critical parameters that modulate the dynamics and the fold change of NF-κB. Both parameters might vary as a result of cell-to-cell variability. The regulation of the IκBα transcription rate constant, e.g. by co-factors, provides the possibility of regulating the NF-κB dynamics by crosstalk.

SUBMITTER: Mothes J 

PROVIDER: S-EPMC4409097 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC2957608 | biostudies-literature
| S-EPMC8678602 | biostudies-literature
| S-EPMC4526340 | biostudies-literature
| S-EPMC7226457 | biostudies-literature
| S-EPMC8565364 | biostudies-literature
| S-EPMC8528867 | biostudies-literature
| S-EPMC1564158 | biostudies-literature
| S-EPMC6305621 | biostudies-literature
| S-EPMC10873160 | biostudies-literature
2010-06-08 | E-GEOD-16193 | biostudies-arrayexpress