Ontology highlight
ABSTRACT:
SUBMITTER: Yamada N
PROVIDER: S-EPMC4526699 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Yamada Norishige N Hasegawa Yuko Y Yue Minghui M Hamada Tomofumi T Nakagawa Shinichi S Ogawa Yuya Y
PLoS genetics 20150805 8
To equalize X-linked gene dosage between the sexes in mammalian females, Xist RNA inactivates one of the two X-chromosomes. Here, we report the crucial function of Xist exon 7 in X-inactivation. Xist exon 7 is the second-largest exon with a well-conserved repeat E in eutherian mammals, but its role is often overlooked in X-inactivation. Although female ES cells with a targeted truncation of the Xist exon 7 showed no significant differences in their Xist expression levels and RNA stability from c ...[more]