Ontology highlight
ABSTRACT:
SUBMITTER: Zheng J
PROVIDER: S-EPMC4526736 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Zheng Jiangge J Lang Yue Y Zhang Qi Q Cui Di D Sun Haili H Jiang Lun L Chen Zhenhang Z Zhang Rui R Gao Yina Y Tian Wenli W Wu Wei W Tang Jun J Chen Zhongzhou Z
Genes & development 20150701 14
The central region of MDM2 is critical for p53 activation and tumor suppression. Upon ribosomal stress, this region is bound by ribosomal proteins, particularly ribosomal protein L11 (RPL11), leading to MDM2 inactivation and subsequent p53 activation. Here, we solved the complex structure of human MDM2-RPL11 at 2.4 Å. MDM2 extensively interacts with RPL11 through an acidic domain and two zinc fingers. Formation of the MDM2-RPL11 complex induces substantial conformational changes in both proteins ...[more]