Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial.

ABSTRACT: BACKGROUND:Both aging and obesity are related to dysregulated immune function, which may be responsible for increased risk of infection and also chronic non-infectious diseases. Dietary lipids have been shown to impact immune and inflammatory responses and cardio-metabolic risk factors. No information on the impact of olive oil on immune responses of overweight and obese older adults is available. OBJECTIVE:We aimed to determine the effect of replacing oils used in a typical American diet with extra virgin olive oil for 3 months on immune responses and cardio-metabolic risk factors in overweight and obese older adults. METHODS:This was a randomized, single-blinded and placebo-controlled trial in 41 overweight or obese participants (aged???65) who consumed a typical American diet. Participants in the control (CON, n?=?21) group were provided with a mixture of corn, soybean oil and butter, and those in the olive oil (OO, n?=?20) group, with extra virgin olive oil, to replace substitutable oils in their diet. At baseline and 3 months, we measured blood pressure, biochemical and immunological parameters using fasting blood, and delayed-type hypersensitivity (DTH) skin response. RESULTS:Compared to the CON group, the OO group showed decreased systolic blood pressure (P?

SUBMITTER: Rozati M 

PROVIDER: S-EPMC4527272 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature