Browse
Submit Data
Databases
API
Help

Dataset Information

14 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Materials and fractal designs for 3D multifunctional integumentary membranes with capabilities in cardiac electrotherapy.

ABSTRACT: Advanced materials and fractal design concepts form the basis of a 3D conformal electronic platform with unique capabilities in cardiac electrotherapies. Fractal geometries, advanced electrode materials, and thin, elastomeric membranes yield a class of device capable of integration with the entire 3D surface of the heart, with unique operational capabilities in low power defibrillation. Co-integrated collections of sensors allow simultaneous monitoring of physiological responses. Animal experiments on Langendorff-perfused rabbit hearts demonstrate the key features of these systems.

SUBMITTER: Xu L

PROVIDER: S-EPMC4527319 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Materials and fractal designs for 3D multifunctional integumentary membranes with capabilities in cardiac electrotherapy.

Xu Lizhi L Gutbrod Sarah R SR Ma Yinji Y Petrossians Artin A Liu Yuhao Y Webb R Chad RC Fan Jonathan A JA Yang Zijian Z Xu Renxiao R Whalen John J JJ Weiland James D JD Huang Yonggang Y Efimov Igor R IR Rogers John A JA

Advanced materials (Deerfield Beach, Fla.) 20150112 10

Advanced materials and fractal design concepts form the basis of a 3D conformal electronic platform with unique capabilities in cardiac electrotherapies. Fractal geometries, advanced electrode materials, and thin, elastomeric membranes yield a class of device capable of integration with the entire 3D surface of the heart, with unique operational capabilities in low power defibrillation. Co-integrated collections of sensors allow simultaneous monitoring of physiological responses. Animal experime ...[more]

PMID: 25641076

Similar Datasets

3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium.

Project description:Means for high-density multiparametric physiological mapping and stimulation are critically important in both basic and clinical cardiology. Current conformal electronic systems are essentially 2D sheets, which cannot cover the full epicardial surface or maintain reliable contact for chronic use without sutures or adhesives. Here we create 3D elastic membranes shaped precisely to match the epicardium of the heart via the use of 3D printing, as a platform for deformable arrays of multifunctional sensors, electronic and optoelectronic components. Such integumentary devices completely envelop the heart, in a form-fitting manner, and possess inherent elasticity, providing a mechanically stable biotic/abiotic interface during normal cardiac cycles. Component examples range from actuators for electrical, thermal and optical stimulation, to sensors for pH, temperature and mechanical strain. The semiconductor materials include silicon, gallium arsenide and gallium nitride, co-integrated with metals, metal oxides and polymers, to provide these and other operational capabilities. Ex vivo physiological experiments demonstrate various functions and methodological possibilities for cardiac research and therapy.

| S-EPMC4521772 | biostudies-literature

Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy.

Project description:Developing advanced surgical tools for minimally invasive procedures represents an activity of central importance to improving human health. A key challenge is in establishing biocompatible interfaces between the classes of semiconductor device and sensor technologies that might be most useful in this context and the soft, curvilinear surfaces of the body. This paper describes a solution based on materials that integrate directly with the thin elastic membranes of otherwise conventional balloon catheters, to provide diverse, multimodal functionality suitable for clinical use. As examples, we present sensors for measuring temperature, flow, tactile, optical and electrophysiological data, together with radiofrequency electrodes for controlled, local ablation of tissue. Use of such 'instrumented' balloon catheters in live animal models illustrates their operation, as well as their specific utility in cardiac ablation therapy. The same concepts can be applied to other substrates of interest, such as surgical gloves.

| S-EPMC3132573 | biostudies-literature

Repurposed Leather with Sensing Capabilities for Multifunctional Electronic Skin.

Project description:Electronic skin (e-skin), an important part toward the realization of artificial intelligence, has been developing through comprehending, mimicking, and eventually outperforming skin in some aspects. Most of the e-skin substrates are flexible polymers, such as polydimethylsiloxane (PDMS). Although PDMS was found to be biocompatible, it is not suitable for long-time wearing due to its air impermeability. This study reports a simple and designable leather based e-skin by merging the natural sophisticated structure and wearing comfort of leather with the multifunctional properties of nanomaterials. The leather based e-skin could make leather, "the dead skin," repurposed for its sensing capabilities. This e-skin can be applied in flexible pressure sensors, displays, user-interactive devices, etc. It provides a new class of materials for the development of multifunctional e-skin to mimic or even outshine the functions of real skin.

| S-EPMC6364595 | biostudies-literature

Engineering the shape and structure of materials by fractal cut.

Project description:In this paper we discuss the transformation of a sheet of material into a wide range of desired shapes and patterns by introducing a set of simple cuts in a multilevel hierarchy with different motifs. Each choice of hierarchical cut motif and cut level allows the material to expand into a unique structure with a unique set of properties. We can reverse-engineer the desired expanded geometries to find the requisite cut pattern to produce it without changing the physical properties of the initial material. The concept was experimentally realized and applied to create an electrode that expands to >800% the original area with only very minor stretching of the underlying material. The generality of our approach greatly expands the design space for materials so that they can be tuned for diverse applications.

| S-EPMC4267358 | biostudies-literature

Multifunctional Bioactive Resin for Dental Restorative Materials.

Project description:Resin-based composites are widely used as dental restorative materials due to their excellent properties. They must have high modulus, high hardness, and be chemically inert while minimizing moisture uptake. To fulfill these higher standard prerequisites and properties, continuous improvements in each of their components are required. This study develops novel composites with multiple biofunctions. Light-cured Bis-GMA/TEGDMA dental resin (RK)/layered double hydroxide intercalated with fluoride ions (LDH-F)/calcium bentonite (Bt) hybrid composites were prepared. The loading ratio of LDH-F to Bt was varied, ranging from 2.5/2.5 to 10/10 parts per hundred RK and structural, mechanical, and biological properties were studied. The incorporation of even small mass fractions (e.g., 2.5 wt % of LDH-F and 2.5 wt % of Bt) in RK dental resin significantly improved the mechanical properties of the pristine resin. The synthetized materials showed antibacterial and antibiofilm effects against three bacterial strains isolated from healthy volunteers' saliva (Streptococcus spp., Bacteroides fragilis, and Staphylococcus epidermidis) without affecting its ability to induce dental pulp stem cells differentiation into odontoblast-like cells. The capability to balance between the antibiofilm activity and dental pulp stem cells differentiation in addition with improved mechanical properties make these materials a promising strategy in preventive and restorative dentistry.

| S-EPMC7077377 | biostudies-literature

Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model.

Project description:The integumentary organ system is a complex system that plays important roles in waterproofing, cushioning, protecting deeper tissues, excreting waste, and thermoregulation. We developed a novel in vivo transplantation model designated as a clustering-dependent embryoid body transplantation method and generated a bioengineered three-dimensional (3D) integumentary organ system, including appendage organs such as hair follicles and sebaceous glands, from induced pluripotent stem cells. This bioengineered 3D integumentary organ system was fully functional following transplantation into nude mice and could be properly connected to surrounding host tissues, such as the epidermis, arrector pili muscles, and nerve fibers, without tumorigenesis. The bioengineered hair follicles in the 3D integumentary organ system also showed proper hair eruption and hair cycles, including the rearrangement of follicular stem cells and their niches. Potential applications of the 3D integumentary organ system include an in vitro assay system, an animal model alternative, and a bioengineered organ replacement therapy.

| S-EPMC4820374 | biostudies-literature

Reconstruction of Soil Components into Multifunctional Freestanding Membranes.

Project description:Multifunctional freestanding membranes are prepared by tuning the structure of ubiquitous soil components, viz. clay and humic acids. Cross-linking of exfoliated clay layers with purified humic acids not only conferred mechanical strength but also enhanced chemical robustness of the membranes. The percolated network of molecularly sized channels of the soil membranes exhibits characteristic nanofluidic phenomena. Electrical conductivity is induced to otherwise insulating soil membranes by heating in an inert atmosphere, without affecting their nanofluidic ionic conductivity. The soil membranes also provided a new platform to prepare and study mixed conducting materials. Strips of heated membranes are shown to exhibit excellent sensitivity toward NH3 gas under atmospheric conditions.

| S-EPMC6648056 | biostudies-literature

Phoamtonic designs yield sizeable 3D photonic band gaps.

Project description:We show that it is possible to construct foam-based heterostructures with complete photonic band gaps. Three-dimensional foams are promising candidates for the self-organization of large photonic networks with combinations of physical characteristics that may be useful for applications. The largest band gap found is based on 3D Weaire-Phelan foam, a structure that was originally introduced as a solution to the Kelvin problem of finding the 3D tessellation composed of equal-volume cells that has the least surface area. The photonic band gap has a maximal size of 16.9% (at a volume fraction of 21.6% for a dielectric contrast [Formula: see text]) and a high degree of isotropy, properties that are advantageous in designing photonic waveguides and circuits. We also present results for 2 other foam-based heterostructures based on Kelvin and C15 foams that have somewhat smaller but still significant band gaps.

| S-EPMC6876150 | biostudies-literature

Molecular Designs for Enhancement of Polarity in Ferroelectric Soft Materials.

Project description:The racemic oxovanadium(IV) salmmen complexes, [VO((rac)-(4-X-salmmen))] (X?=?C12C10C5 (1), C16 (2), and C18 (3); salmmen?=?N,N'-monomethylenebis-salicylideneimine) with "banana shaped" molecular structures were synthesized, and their ferroelectric properties were investigated. These complexes exhibit well-defined hysteresis loops in their viscous phases, moreover, 1 also displays liquid crystal behaviour. We observed a synergetic effect influenced by three structural aspects; the methyl substituents on the ethylene backbone, the banana shaped structure and the square pyramidal metal cores all play an important role in generating the observed ferroelectricity, pointing the way to a useful strategy for the creation of advanced ferroelectric soft materials.

| S-EPMC4645115 | biostudies-literature

Soft three-dimensional network materials with rational bio-mimetic designs.

Project description:Many biological tissues offer J-shaped stress-strain responses, since their microstructures exhibit a three-dimensional (3D) network construction of curvy filamentary structures that lead to a bending-to-stretching transition of the deformation mode under an external tension. The development of artificial 3D soft materials and device systems that can reproduce the nonlinear, anisotropic mechanical properties of biological tissues remains challenging. Here we report a class of soft 3D network materials that can offer defect-insensitive, nonlinear mechanical responses closely matched with those of biological tissues. This material system exploits a lattice configuration with different 3D topologies, where 3D helical microstructures that connect the lattice nodes serve as building blocks of the network. By tailoring geometries of helical microstructures or lattice topologies, a wide range of desired anisotropic J-shaped stress-strain curves can be achieved. Demonstrative applications of the developed conducting 3D network materials with bio-mimetic mechanical properties suggest potential uses in flexible bio-integrated devices.

| S-EPMC7055264 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data