Structural Hot Spots Determine Functional Diversity of the Candida glabrata Epithelial Adhesin Family.
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ABSTRACT:
SUBMITTER: Diderrich R
PROVIDER: S-EPMC4528126 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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Structural Hot Spots Determine Functional Diversity of the Candida glabrata Epithelial Adhesin Family.
Diderrich Rike R Kock Michael M Maestre-Reyna Manuel M Keller Petra P Steuber Holger H Rupp Steffen S Essen Lars-Oliver LO Mösch Hans-Ulrich HU
The Journal of biological chemistry 20150623 32
For host colonization, the human fungal pathogen Candida glabrata is known to utilize a large family of highly related surface-exposed cell wall proteins, the lectin-like epithelial adhesins (Epas). To reveal the structure-function relationships within the entire Epa family, we have performed a large scale functional analysis of the adhesion (A) domains of 17 Epa paralogs in combination with three-dimensional structural studies of selected members with cognate ligands. Our study shows that most ...[more]
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