Ontology highlight
ABSTRACT:
SUBMITTER: Ganesan A
PROVIDER: S-EPMC4770091 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Ganesan Ashok A Siekierska Aleksandra A Beerten Jacinte J Brams Marijke M Van Durme Joost J De Baets Greet G Van der Kant Rob R Gallardo Rodrigo R Ramakers Meine M Langenberg Tobias T Wilkinson Hannah H De Smet Frederik F Ulens Chris C Rousseau Frederic F Schymkowitz Joost J
Nature communications 20160224
Natural selection shapes protein solubility to physiological requirements and recombinant applications that require higher protein concentrations are often problematic. This raises the question whether the solubility of natural protein sequences can be improved. We here show an anti-correlation between the number of aggregation prone regions (APRs) in a protein sequence and its solubility, suggesting that mutational suppression of APRs provides a simple strategy to increase protein solubility. W ...[more]