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Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma.


ABSTRACT: We sought to identify a serum miRNA expression profile to improve disease surveillance and to predict post-operative disease recurrence for stage II/III colorectal cancer (CRC) patients. Using the TaqMan Low-Density Array (TLDA), we performed an initial survey to analyze 749 miRNAs in the pooled serum of 20 paired pre- and post-operative CRC patients and 20 matched normal subjects. Using individual RT-qPCR verification in 175 stage II/III CRC patients, we identified that miR-145, miR-106a and miR-17-3p were significantly differentially expressed between pre- and post-operative CRC patients and between pre-operative CRC patients and normal controls (P?

SUBMITTER: Li J 

PROVIDER: S-EPMC4528229 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Serum miRNA expression profile as a prognostic biomarker of stage II/III colorectal adenocarcinoma.

Li Jialu J   Liu Yang Y   Wang Cheng C   Deng Ting T   Liang Hongwei H   Wang Yifei Y   Huang Dingzhi D   Fan Qian Q   Wang Xia X   Ning Tao T   Liu Rui R   Zhang Chen-Yu CY   Zen Ke K   Chen Xi X   Ba Yi Y  

Scientific reports 20150807


We sought to identify a serum miRNA expression profile to improve disease surveillance and to predict post-operative disease recurrence for stage II/III colorectal cancer (CRC) patients. Using the TaqMan Low-Density Array (TLDA), we performed an initial survey to analyze 749 miRNAs in the pooled serum of 20 paired pre- and post-operative CRC patients and 20 matched normal subjects. Using individual RT-qPCR verification in 175 stage II/III CRC patients, we identified that miR-145, miR-106a and mi  ...[more]

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