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Xylooligosaccharide supplementation alters gut bacteria in both healthy and prediabetic adults: a pilot study.

ABSTRACT: BACKGROUND:It has been suggested that gut microbiota is altered in Type 2 Diabetes Mellitus (T2DM) patients. OBJECTIVE:This study was to evaluate the effect of the prebiotic xylooligosaccharide (XOS) on the gut microbiota in both healthy and prediabetic (Pre-DM) subjects, as well as impaired glucose tolerance (IGT) in Pre-DM. SUBJECTS/METHODS:Pre-DM (n = 13) or healthy (n = 16) subjects were randomized to receive 2 g/day XOS or placebo for 8-weeks. In Pre-DM subjects, body composition and oral glucose tolerance test (OGTT) was done at baseline and week 8. Stool from Pre-DM and healthy subjects at baseline and week 8 was analyzed for gut microbiota characterization using Illumina MiSeq sequencing. RESULTS:We identified 40 Pre-DM associated bacterial taxa. Among them, the abundance of the genera Enterorhabdus, Howardella, and Slackia was higher in Pre-DM. XOS significantly decreased or reversed the increase in abundance of Howardella, Enterorhabdus, and Slackia observed in healthy or Pre-DM subjects. Abundance of the species Blautia hydrogenotrophica was lower in pre-DM subjects, while XOS increased its abundance. In Pre-DM, XOS showed a tendency to reduce OGTT 2-h insulin levels (P = 0.13), but had no effect on body composition, HOMA-IR, serum glucose, triglyceride, satiety hormones, and TNF?. CONCLUSION:This is the first clinical observation of modifications of the gut microbiota by XOS in both healthy and Pre-DM subjects in a pilot study. Prebiotic XOS may be beneficial in reversing changes in the gut microbiota during the development of diabetes. CLINICAL TRIAL REGISTRATION:NCT01944904 (https://clinicaltrials.gov/ct2/show/NCT01944904).

SUBMITTER: Yang J

PROVIDER: S-EPMC4528259 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Xylooligosaccharide supplementation alters gut bacteria in both healthy and prediabetic adults: a pilot study.

Yang Jieping J Summanen Paula H PH Henning Susanne M SM Hsu Mark M Lam Heiman H Huang Jianjun J Tseng Chi-Hong CH Dowd Scot E SE Finegold Sydney M SM Heber David D Li Zhaoping Z

Frontiers in physiology 20150807

<h4>Background</h4>It has been suggested that gut microbiota is altered in Type 2 Diabetes Mellitus (T2DM) patients.<h4>Objective</h4>This study was to evaluate the effect of the prebiotic xylooligosaccharide (XOS) on the gut microbiota in both healthy and prediabetic (Pre-DM) subjects, as well as impaired glucose tolerance (IGT) in Pre-DM.<h4>Subjects/methods</h4>Pre-DM (n = 13) or healthy (n = 16) subjects were randomized to receive 2 g/day XOS or placebo for 8-weeks. In Pre-DM subjects, body ...[more]

PMID: 26300782

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Xylooligosaccharide supplementation alters gut bacteria in both healthy and prediabetic adults: a pilot study.

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Xylooligosaccharide supplementation alters gut bacteria in both healthy and prediabetic adults: a pilot study.

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