Ontology highlight
ABSTRACT:
SUBMITTER: Zarnitsyna VI
PROVIDER: S-EPMC4528424 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Zarnitsyna Veronika I VI Ellebedy Ali H AH Davis Carl C Jacob Joshy J Ahmed Rafi R Antia Rustom R
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20150901 1676
The immune responses to influenza, a virus that exhibits strain variation, show complex dynamics where prior immunity shapes the response to the subsequent infecting strains. Original antigenic sin (OAS) describes the observation that antibodies to the first encountered influenza strain, specifically antibodies to the epitopes on the head of influenza's main surface glycoprotein, haemagglutinin (HA), dominate following infection with new drifted strains. OAS suggests that responses to the origin ...[more]