Ontology highlight
ABSTRACT:
SUBMITTER: Rosenbaum MA
PROVIDER: S-EPMC4529116 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Rosenbaum Michael A MA Chaudhuri Pinaki P Abelson Benjamin B Cross Brandy N BN Graham Linda M LM
Atherosclerosis 20150618 2
<h4>Objective</h4>Endothelial cell (EC) migration is essential for healing of arterial injuries caused by angioplasty, but a high cholesterol diet inhibits endothelial repair. In vivo studies suggest that apolipoprotein A-I (apoA-I), the major protein constituent of HDL, is essential for normal healing of arterial injuries. ApoA-I mimetics, including 4F, have been designed to mimic the amphipathic portion of the apoA-I molecule. This study was undertaken to determine if 4F improves endothelial m ...[more]