Ontology highlight
ABSTRACT:
SUBMITTER: McCall JG
PROVIDER: S-EPMC4529361 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
McCall Jordan G JG Al-Hasani Ream R Siuda Edward R ER Hong Daniel Y DY Norris Aaron J AJ Ford Christopher P CP Bruchas Michael R MR
Neuron 20150723 3
The locus coeruleus noradrenergic (LC-NE) system is one of the first systems engaged following a stressful event. While numerous groups have demonstrated that LC-NE neurons are activated by many different stressors, the underlying neural circuitry and the role of this activity in generating stress-induced anxiety has not been elucidated. Using a combination of in vivo chemogenetics, optogenetics, and retrograde tracing, we determine that increased tonic activity of the LC-NE system is necessary ...[more]