RNA-binding residues prediction using structural features.

ABSTRACT:

Background

RNA-protein complexes play an essential role in many biological processes. To explore potential functions of RNA-protein complexes, it's important to identify RNA-binding residues in proteins.

Results

In this work, we propose a set of new structural features for RNA-binding residue prediction. A set of template patches are first extracted from RNA-binding interfaces. To construct structural features for a residue, we compare its surrounding patches with each template patch and use the accumulated distances as its structural features. These new features provide sufficient structural information of surrounding surface of a residue and they can be used to measure the structural similarity between the surface surrounding two residues. The new structural features, toge

SUBMITTER: Ren H 

PROVIDER: S-EPMC4529986 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature