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Fully-automated synthesis of 16?-(18)F-fluoro-5?-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer.

ABSTRACT: Noninvasive in vivo imaging of androgen receptor (AR) levels with positron emission tomography (PET) is becoming the primary tool in prostate cancer detection and staging. Of the potential (18)F-labeled PET tracers, (18)F-FDHT has clinically shown to be of highest diagnostic value. We demonstrate the first automated synthesis of (18)F-FDHT by adapting the conventional manual synthesis onto the fully-automated ELIXYS radiosynthesizer. Clinically-relevant amounts of (18)F-FDHT were synthesized on ELIXYS in 90 min with decay-corrected radiochemical yield of 29±5% (n=7). The specific activity was 4.6 Ci/µmol (170 GBq/µmol) at end of formulation with a starting activity of 1.0 Ci (37 GBq). The formulated (18)F-FDHT yielded sufficient activity for multiple patient doses and passed all quality control tests required for routine clinical use.

SUBMITTER: Lazari M 

PROVIDER: S-EPMC4530021 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer.

Lazari Mark M   Lyashchenko Serge K SK   Burnazi Eva M EM   Lewis Jason S JS   van Dam R Michael RM   Murphy Jennifer M JM  

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20150521

Noninvasive in vivo imaging of androgen receptor (AR) levels with positron emission tomography (PET) is becoming the primary tool in prostate cancer detection and staging. Of the potential (18)F-labeled PET tracers, (18)F-FDHT has clinically shown to be of highest diagnostic value. We demonstrate the first automated synthesis of (18)F-FDHT by adapting the conventional manual synthesis onto the fully-automated ELIXYS radiosynthesizer. Clinically-relevant amounts of (18)F-FDHT were synthesized on  ...[more]

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