Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.
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ABSTRACT:
SUBMITTER: Kikuta S
PROVIDER: S-EPMC4530460 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.
Kikuta Satomi S Nakamura Yukiyo Y Yamamura Yukio Y Tamura Atsushi A Homma Noriyasu N Yanagawa Yuchio Y Tamura Hajime H Kasahara Jiro J Osanai Makoto M
Scientific reports 20150810
We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson's disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD s ...[more]
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